Endocrine Abstracts

Silent Corticotroph Adenomas (SCAs) are a type of pituitary tumor that is discovered without obvious clinical symptoms. SCAs are considered to be one of the five "high-risk" tumors due to their aggressive behavior, characterized by high levels of proliferation, rapid progression, and recurrence. Unlike functional corticotropin adenomas, SCAs do not exhibit any clinical or biochemical signs of hypercortisolemia. When the tumor is detected, it often exhibits invasive gro...

The ability of local invasion and distant metastasis indicates malignancy. Focal adhesion complex plays an important role during cell invasion. This complex consists of integrins, focal adhesion kinase (FAK), vinculin, talin, α-actinin and paxillin. Activation of FAK regulates the assembly of focal adhesion and stress fiber formation via GTPase Rho and Rac, which is responsible for the migratory behavior of cells. In this study, we demonstrated the inhibitory effect of ro...

Objective: Studies have demonstrated that patients with acromegaly have compromised bone health and an increased risk of vertebral fractures (VFs). However, the prevalence of VFs in Chinese patients with acromegaly has not been investigated by far. This study aimed to evaluate the prevalence and determinants of VFs in patients with acromegaly in a tertiary hospital in China.Methods: We enrolled patients diagnosed with acromegaly consecutively at West Chi...

Objective: To summarise and analyze the pathogenesis, clinical risk assessment, and treatment of venous thromboembolic events (VTE) associated with Cushing syndrome (CS), and to improve clinicians’ understanding of this complication.Methods: The clinical diagnosis and treatment of 3 patients with Cushing disease (CD) combined with pulmonary embolism were reviewed, and relevant literature at home and abroad was reviewed.Results...

Endocrine-Related Cancer, 2019, 27(2): 81–95 (DOI: https://doi.org/10.1530/ERC-19-0095)...